Issue 26, 2013

A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

Abstract

The first multicomponent catalytic asymmetric synthesis of spiroacetals has been described. Hybrid molecules comprising a spiroacetal scaffold (a natural-product inspired scaffold) and an α-amino acid motif (a privileged fragment) are easily available through a gold phosphate-catalysed one-pot three component coupling reaction of alkynols, anilines and glyoxylic acid.

Graphical abstract: A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

Supplementary files

Article information

Article type
Communication
Submitted
06 Jan 2013
Accepted
12 Feb 2013
First published
13 Feb 2013

Chem. Commun., 2013,49, 2715-2717

A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

L. Cala, A. Mendoza, F. J. Fañanás and F. Rodríguez, Chem. Commun., 2013, 49, 2715 DOI: 10.1039/C3CC00118K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements