Issue 12, 2013
From the journal:

Chemical Communications

Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins†

Takumi Yamaguchi,ab   Tsuyoshi Uno,ab   Yoshinori Uekusa,ab   Maho Yagi-Utsumiab  and  Koichi Kato*ab  

* Corresponding authors

a Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 5-1 Higashiyama Myodaiji, Okazaki 444-8787, Japan
E-mail: kkatonmr@ims.ac.jp
Fax: +81 564 59 5224

b Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Japan

Abstract

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.

Graphical abstract: Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

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Article information

DOI
https://doi.org/10.1039/C2CC38016A
Article type
Communication
Submitted
06 Nov 2012
Accepted
19 Dec 2012
First published
19 Dec 2012

Chem. Commun., 2013,49, 1235-1237

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Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

T. Yamaguchi, T. Uno, Y. Uekusa, M. Yagi-Utsumi and K. Kato, Chem. Commun., 2013, 49, 1235 DOI: 10.1039/C2CC38016A

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