Issue 5, 2013
From the journal:

Chemical Communications

Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein–protein interactions†

Yurii S. Moroz,a   Wolfgang Binder,ab   Patrik Nygren,c   Gregory A. Caputod  and  Ivan V. Korendovych*a  

* Corresponding authors

a Department of Chemistry, Syracuse University, 111 College Place, Syracuse, NY 13244, USA
E-mail: ikorendo@syr.edu
Fax: +1 315 443 4070
Tel: +1 315 443 1661

b Department of Chemistry, Graz University of Technology, Graz, Austria

c Department of Hematology and Oncology, University of Pennsylvania Medical School, Philadelphia, PA 19014, USA

d Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA

Abstract

We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein–protein interactions while not perturbing them.

Graphical abstract: Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein–protein interactions

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Article information

DOI
https://doi.org/10.1039/C2CC37550H
Article type
Communication
Submitted
16 Oct 2012
Accepted
20 Nov 2012
First published
21 Nov 2012

Chem. Commun., 2013,49, 490-492

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Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying protein–protein interactions

Y. S. Moroz, W. Binder, P. Nygren, G. A. Caputo and I. V. Korendovych, Chem. Commun., 2013, 49, 490 DOI: 10.1039/C2CC37550H

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