Issue 15, 2013
From the journal:

Chemical Communications

ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes†

Philip Andrews,a   Christopher M. Latham,a   Marc Magre,a   Darren Willcoxa  and  Simon Woodward*a  

* Corresponding authors

a School of Chemistry, The University of Nottingham, University Park, Nottingham, UK
E-mail: simon.woodward@nottingham.ac.uk
Fax: +44 (0)115 9513564
Tel: +44 (0)115 9513541

Abstract

Stabilized AlHCl2·(THF)2 hydroaluminates RC[triple bond, length as m-dash]CH with exceptional chemo-, regio- and stereoselectivity under efficient ZrCl2(η-C5Me5)2 catalysis (2–5 mol%). The resulting vinyl alanes undergo palladium cross-coupling with a wide range of sp2 electrophiles (aryl, heteroaryl and vinyl halides/pseudohalides) in good to excellent yields.

Graphical abstract: ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes

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Article information

DOI
https://doi.org/10.1039/C2CC37537K
Article type
Communication
Submitted
16 Oct 2012
Accepted
06 Nov 2012
First published
14 Jan 2013

Chem. Commun., 2013,49, 1488-1490

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ZrCl2(η-C5Me5)2-AlHCl2·(THF)2: efficient hydroalumination of terminal alkynes and cross-coupling of the derived alanes

P. Andrews, C. M. Latham, M. Magre, D. Willcox and S. Woodward, Chem. Commun., 2013, 49, 1488 DOI: 10.1039/C2CC37537K

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