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Issue 39, 2013
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Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis

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Abstract

Copper catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions. A hydrometallation-catalytic asymmetric 1,4-addition was used to synthesize either enantiomer of a natural product in one step from commercially available materials. Hydrometallation-addition sequences applied to steroids containing a cross-conjugated dienone or 1,6-acceptor give highly functionalized products.

Graphical abstract: Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis

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Publication details

The article was received on 01 Oct 2012, accepted on 19 Nov 2012 and first published on 20 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37155C
Chem. Commun., 2013,49, 4211-4213

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    Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis

    R. M. Maksymowicz, P. M. C. Roth, A. L. Thompson and S. P. Fletcher, Chem. Commun., 2013, 49, 4211
    DOI: 10.1039/C2CC37155C

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