Issue 21, 2013

Acid-degradable polymers for drug delivery: a decade of innovation

Abstract

Polymers that start degrading under acidic conditions are increasingly investigated as a pathway to trigger the release of drugs once the drug carrier reached the slightly acidic tumour environment or after the drug carrier has been taken up by cells, resulting in the localization of the polymer in the acidic endosomes and lysosomes. The advances in the design of acid-degradable polymers and drug delivery systems have been summarized and discussed in this review article. Various acid-labile groups such as acetals, orthoester, hydrazones, imines and cis-aconityl, that can undergo cleavage in slightly acidic conditions, have been employed to create polymer architectures or polymer–drug conjugates that can degrade under lysosomal and endosomal conditions, triggering the fast release of drugs or DNA.

Graphical abstract: Acid-degradable polymers for drug delivery: a decade of innovation

Article information

Article type
Feature Article
Submitted
11 Sep 2012
Accepted
07 Dec 2012
First published
10 Dec 2012

Chem. Commun., 2013,49, 2082-2102

Acid-degradable polymers for drug delivery: a decade of innovation

S. Binauld and M. H. Stenzel, Chem. Commun., 2013, 49, 2082 DOI: 10.1039/C2CC36589H

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