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Issue 26, 2013
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Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

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Abstract

The selective trifluoromethylation of aryl- and vinylboronic acids proceeds smoothly with CF3SO2Na (Langlois reagent) in the presence of copper catalysts and t-BuOOH. Therefore, the method relies both on transition metal catalysis and selective radical reactions. Advantageously, the protocol can be performed at room temperature under an air atmosphere and avoids the issue of poor regioselectivity.

Graphical abstract: Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

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Supplementary files

Article information


Submitted
09 Sep 2012
Accepted
17 Dec 2012
First published
17 Dec 2012

Chem. Commun., 2013,49, 2628-2630
Article type
Communication

Copper-catalyzed trifluoromethylation of aryl- and vinylboronic acids with generation of CF3-radicals

Y. Li, L. Wu, H. Neumann and M. Beller, Chem. Commun., 2013, 49, 2628
DOI: 10.1039/C2CC36554E

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