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Issue 10, 2013
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Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

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Abstract

Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N–H of the imidazole and O4 of the uracil nucleobase.

Graphical abstract: Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

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Supplementary files

Article information


Submitted
02 Sep 2012
Accepted
21 Nov 2012
First published
19 Dec 2012

Chem. Commun., 2013,49, 999-1001
Article type
Communication

Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

D. B. Gophane and S. Th. Sigurdsson, Chem. Commun., 2013, 49, 999
DOI: 10.1039/C2CC36389E

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