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Issue 18, 2013
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Expansion of the aptamer library from a “natural soup” to an “unnatural soup”

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Abstract

The possibility of evolving a commonly existing biomolecule into a variety of functional biomolecules has now been realized in the form of aptamers through the development of in vitro selection. In addition to their high affinity and high specificity for the desired targets, aptamers are easily synthesized chemically and can be modified for downstream applications. Although aptamers were originally selected from a library containing only natural components, the past decade has seen a wealth of new aptamers selected from libraries containing unnatural components to provide new aptamer functions artificially. In this review, we highlight this transition (the shift between selection from natural components and selection from unnatural components) and the applications of selected aptamers.

Graphical abstract: Expansion of the aptamer library from a “natural soup” to an “unnatural soup”

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Publication details

The article was received on 31 Aug 2012, accepted on 07 Dec 2012 and first published on 02 Jan 2013


Article type: Feature Article
DOI: 10.1039/C2CC36348H
Chem. Commun., 2013,49, 1786-1795

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    Expansion of the aptamer library from a “natural soup” to an “unnatural soup”

    T. Uzawa, S. Tada, W. Wang and Y. Ito, Chem. Commun., 2013, 49, 1786
    DOI: 10.1039/C2CC36348H

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