Jump to main content
Jump to site search

Issue 1, 2013
Previous Article Next Article

Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy

Author affiliations

Abstract

A new modality of using ultrasound irradiation instead of photoactivation, as in photodynamic therapy (PDT), sonodynamic therapy, has emerged as a promising treatment for various types of cancer. Titanium dioxide (TiO2) has the ability to generate reactive oxygen species (ROS) by not only photo- but also ultrasound-irradiation. Here, the formation of core–shell type polyion complex micelles from TiO2 nanoparticles with polyallylamine bearing poly(ethylene glycol) grafts effectively improves the dispersion stability of the TiO2 nanoparticles under physiological conditions for therapeutic application. The TiO2 nanoparticles in the micelles can generate ROS including singlet oxygen (1O2) by sonication. Furthermore, the micelles are taken up into HeLa cells and the TiO2 nanoparticles generate 1O2, which is widely believed to be the main cytotoxic agent in PDT, even in the cells treated by sonication. This is the first result representing 1O2 generation of TiO2 nanoparticles in HeLa cells by sonication. Further, the micelles can selectively exhibit a cell-killing effect at only the ultrasound-irradiated area.

Graphical abstract: Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Jun 2012, accepted on 29 Jun 2012 and first published on 26 Sep 2012


Article type: Paper
DOI: 10.1039/C2BM00066K
Citation: Biomater. Sci., 2013,1, 65-73
  •   Request permissions

    Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy

    A. Harada, M. Ono, E. Yuba and K. Kono, Biomater. Sci., 2013, 1, 65
    DOI: 10.1039/C2BM00066K

Search articles by author

Spotlight

Advertisements