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Issue 19, 2013
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Liquid-phase separation of structurally similar steroids using phenyl stationary phases

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Abstract

The selectivity of different phenyl HPLC stationary phases has been evaluated with respect to structurally similar steroids, including sapogenins of plant origin. A column packing containing a biphenyl ligand was best at separating species that differed with respect to their degree of unsaturation. A diphenyl phase performed better than the biphenyl column in separating steroid epimers, but the best phase for epimer separation was octadecasilyl-bonded silica. The various mechanisms responsible for these results are discussed.

Graphical abstract: Liquid-phase separation of structurally similar steroids using phenyl stationary phases

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Article information


Submitted
24 May 2013
Accepted
17 Jul 2013
First published
19 Jul 2013

Anal. Methods, 2013,5, 5014-5018
Article type
Paper

Liquid-phase separation of structurally similar steroids using phenyl stationary phases

M. Powell and M. B. D'Arcy, Anal. Methods, 2013, 5, 5014
DOI: 10.1039/C3AY40875B

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