Issue 9, 2013
From the journal:

Analytical Methods

Evaluation of micro ultra high pressure liquid chromatography for pharmaceutical analysis

Monica (Mei) Yang,*a   Xiaoyi Gong,*b   Wes Schafer,b   Don Arnoldc  and  Christopher J. Welchb  

* Corresponding authors

a Analytical Development and Commercialization, Merck & Co., Inc., RY818-A211, P. O. Box 2000, Rahway, NJ 07065, USA
E-mail: monica_yang@merck.com
Fax: +1-732-594-3887
Tel: +1-732-594-6698

b Analytical Chemistry, Merck & Co., Inc., RY818-B222, P. O. Box 2000, Rahway, NJ 07065, USA
E-mail: xiaoyi_gong@merck.com
Fax: +1-732-594-3887
Tel: +1 1-732-594-5703

c Eksigent, part of AB SCIEX, Dublin, CA, USA

Abstract

The Eksigent ExpressLC Ultra micro high pressure LC system was evaluated and found to provide separation efficiency and system reproducibility comparable with conventional HPLC instruments, albeit with somewhat higher UV detector noise. The dwell volume of the system was measured and found to be extremely small compared with conventional HPLC and UHPLC system which makes the Eksigent micro UHPLC an excellent choice for super fast gradient separation.

Graphical abstract: Evaluation of micro ultra high pressure liquid chromatography for pharmaceutical analysis

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C3AY26435A
Article type
Paper
Submitted
21 Nov 2012
Accepted
01 Mar 2013
First published
04 Mar 2013

Anal. Methods, 2013,5, 2178-2181

Permissions

Request permissions

Evaluation of micro ultra high pressure liquid chromatography for pharmaceutical analysis

M. (. Yang, X. Gong, W. Schafer, D. Arnold and C. J. Welch, Anal. Methods, 2013, 5, 2178 DOI: 10.1039/C3AY26435A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements