Issue 23, 2013

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Abstract

The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.

Graphical abstract: Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2013
Accepted
26 Sep 2013
First published
26 Sep 2013
This article is Open Access
Creative Commons BY license

Analyst, 2013,138, 7070-7074

Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

J. Charles. G. Jeynes, C. Jeynes, M. J. Merchant and K. J. Kirkby, Analyst, 2013, 138, 7070 DOI: 10.1039/C3AN01406A

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