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Issue 15, 2013
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An aptasensor for electrochemical detection of tumor necrosis factor in human blood

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Abstract

Electrochemical aptasensors can detect disease markers such as cytokines to provide point-of-care diagnosis that is low-cost, rapid, specific and sensitive. Herein, we describe the development of an aptamer-based electrochemical sensor for detection and analysis of tumor necrosis factor-alpha (TNF-α) – a key inflammatory cytokine – in whole human blood. When testing spiked blood, a TNF-α detection limit of 58 pM (10 ng mL−1) and a linear range of 6 nM (100 ng mL−1) could be achieved. Furthermore, detection of TNF-α in mitogen stimulated whole blood was demonstrated.

Graphical abstract: An aptasensor for electrochemical detection of tumor necrosis factor in human blood

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Supplementary files

Article information


Submitted
23 Apr 2013
Accepted
03 May 2013
First published
08 May 2013

Analyst, 2013,138, 4321-4326
Article type
Paper

An aptasensor for electrochemical detection of tumor necrosis factor in human blood

Y. Liu, Q. Zhou and A. Revzin, Analyst, 2013, 138, 4321
DOI: 10.1039/C3AN00818E

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