Bioorganic hybrid OMS by straightforward grafting of trialkoxysilyl peptides

Abstract

A novel strategy for the synthesis of peptide–bioorganic hybrid silica materials is reported. It relies on the design of hybrid peptides bearing a trialkoxysilane group. These reactive monomers are covalently attached to silica without requiring any prior surface modification. As an example, a bioorganic–inorganic OMS aldolisation catalyst is prepared using the peptide sequence Pro-Pro-Asp-Lys.