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Issue 18, 2013
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Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications

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Abstract

Medical adhesives and sealants often require that long-term adhesiveness is achieved. In this work, nanostructured coatings consisting of chitosan and the adhesive bacterial exopolysaccharide levan are fabricated using layer-by-layer (LbL) assembly. Taking advantage of the electrostatic self-assembly mechanism of LbL, the charges of both chitosan and a phosphonate-derivatized levan (Ph-levan) are measured and the feasibility of constructing hybrid films is monitored and confirmed using a quartz crystal microbalance with dissipation monitoring (QCM-D). The adhesive properties between two identical bonded films with a total of 100 layers are compared to control films in which Ph-levan is replaced by alginate, revealing that the detachment force of the former is about 3 times higher than the control. Scanning electron microscopy of the films surface shows that the surface of Ph-levan films is smooth and homogeneous. Cell adhesion tests were conducted using a L929 cell line. Early cell adhesion is significantly higher in chitosan/Ph-levan films when compared to chitosan/alginate controls. These findings establish levan derivatives as bioinspired ingredients for conceiving medical adhesive devices that allow achieving enhanced mechanical and biological performance.

Graphical abstract: Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications

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Article information


Submitted
29 Jan 2013
Accepted
05 Mar 2013
First published
05 Mar 2013

J. Mater. Chem. B, 2013,1, 2367-2374
Article type
Paper

Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications

R. R. Costa, A. I. Neto, I. Calgeris, C. R. Correia, A. C. M. Pinho, J. Fonseca, E. T. Öner and J. F. Mano, J. Mater. Chem. B, 2013, 1, 2367
DOI: 10.1039/C3TB20137F

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