Jump to main content
Jump to site search

Issue 3, 2013
Previous Article Next Article

Biodegradable polymer–lipid monolayers as templates for calcium phosphate mineralization

Author affiliations

Abstract

A combination of poly([R]-3-hydroxy-10-undecenoate) (PHUE), a biodegradable polymer from the group of polyhydroxyalkanoates (PHAs), and lipids of different head groups was used to support the growth of calcium phosphate, the main component of mammalian bones. Crystallization took place under two-dimensional films (Langmuir monolayers). The addition of a negatively charged lipid, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine, to a PHUE film led to the formation of lipid domains (rich in negative charge), and resulted in excellent mineralization control: crystals with uniform size and morphology were formed. The results show that carefully optimized combinations of materials can lead to better control of calcium phosphate crystallization compared to one-component organic scaffolds.

Graphical abstract: Biodegradable polymer–lipid monolayers as templates for calcium phosphate mineralization

Back to tab navigation

Supplementary files

Article information


Submitted
05 Sep 2012
Accepted
31 Oct 2012
First published
15 Nov 2012

J. Mater. Chem. B, 2013,1, 368-378
Article type
Paper

Biodegradable polymerlipid monolayers as templates for calcium phosphate mineralization

A. Jagoda, M. Zinn, E. Bieler, W. Meier and K. Kita-Tokarczyk, J. Mater. Chem. B, 2013, 1, 368
DOI: 10.1039/C2TB00083K

Social activity

Search articles by author

Spotlight

Advertisements