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Issue 25, 2013
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Submicron hybrid vesicles consisting of polymer–lipid and polymer–cholesterol blends

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Hybrid polymerlipid and polymercholesterol submicron unilamellar vesicles with a diameter of ∼200 nm based on poly(dimethylsiloxane)-block-poly(2-methyl-oxazoline) (PDMS-b-PMOXA) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were prepared by using the film-hydration and extrusion method. The vesicles were extensively characterized via dynamic and static light scattering (DLS and SLS), dual-color fluorescence cross-correlation spectroscopy (DC-FCCS), cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy imaging and force spectroscopy (AFM). The combination of these techniques provides information about the vesicle size, shape and long-term stability as well as the mechanical properties. DC-FCCS proved the formation of hybrid vesicles containing both components. Cryo-TEM and AFM studies revealed that the presence of cholesterol in vesicle membranes leads to a higher packing density resulting in a reduced membrane thickness and a significantly increased bending stiffness compared to pure polymersomes and polymerlipid vesicles.

Graphical abstract: Submicron hybrid vesicles consisting of polymer–lipid and polymer–cholesterol blends

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Supplementary files

Article information

14 Mar 2013
21 Apr 2013
First published
15 May 2013

Soft Matter, 2013,9, 5883-5890
Article type

Submicron hybrid vesicles consisting of polymerlipid and polymercholesterol blends

S. Winzen, M. Bernhardt, D. Schaeffel, A. Koch, M. Kappl, K. Koynov, K. Landfester and A. Kroeger, Soft Matter, 2013, 9, 5883
DOI: 10.1039/C3SM50733E

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