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Issue 16, 2013

Interpolyelectrolyte complexes based on hyaluronic acid-block-poly(ethylene glycol) and poly-l-lysine

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Abstract

The preparation of spherical, nanosized interpolyelectrolyte complexes by the interaction of hyaluronic acid-block-poly(ethylene glycol) (HA-b-PEG) with poly-L-lysine (PLL) at a stoichiometric charge-to-charge ratio is described. The complexation was studied by dynamic light scattering and cryogenic transmission electron microscopy for HA-b-PEG with different lengths of the HA and PEG blocks. A minimal molecular weight of the HA block (ca. 9 kDa) is necessary for efficient complexation, while a minimal molecular weight of the PEG block (ca. 5 kDa) is needed to prevent macroscopic aggregation. The formed nanoassemblies have hydrodynamic radii ranging from 45 to 150 nm with very low dispersity indices (D.I. = 0.02–0.05). They appear as soft objects with a nanogel structure and pronouncedly swell on addition of NaCl. The increasing ionic strength leads to disruption of the complexes above ca. 120–160 mM of NaCl. Decreasing the ionic strength by dialysis reforms the nanogels, demonstrating the reversibility of nanogel formation. Crosslinking with carbodiimide leads to nanoassemblies with a very well defined structure and high stability against ionic strength.

Graphical abstract: Interpolyelectrolyte complexes based on hyaluronic acid-block-poly(ethylene glycol) and poly-l-lysine

Supplementary files

Article information


Submitted
05 Nov 2012
Accepted
01 Feb 2013
First published
12 Mar 2013

Soft Matter, 2013,9, 4297-4303
Article type
Paper

Interpolyelectrolyte complexes based on hyaluronic acid-block-poly(ethylene glycol) and poly-L-lysine

R. Novoa-Carballal, D. V. Pergushov and A. H. E. Müller, Soft Matter, 2013, 9, 4297 DOI: 10.1039/C3SM27549C

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