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Issue 21, 2013
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Interactions and visualization of bio-mimetic membrane detachment at smooth and nano-rough gold electrode surfaces

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Abstract

Non-specific physical and specific chemical interactions of cells, bacteria, and biomembranes with non-biological target surfaces (e.g., metallic and metal oxides) are crucial in determining the interfacial behavior (interaction forces, adhesion, local deformations and structuring) of many bio- and nano-inspired materials. Knowledge of the governing interactions provides physicochemical understanding of biological systems, and enables engineering of new nano-systems for biomaterials or biomedical benefit. We have directly measured and visualized membrane adhesion and detachment at nanoscopic and extended rough gold electrode surfaces through a multi-scale approach: interactions and contact mechanics measured by surface forces apparatus (SFA) are in quantitative agreement with atomic force microscopy (AFM) measurements, both of which show that membranes can strongly adhere to rough gold surfaces and asperities via specific amine–gold binding and non-specific hydrophobic interactions. The results give insights into membrane interactions at smooth and rough metallic surfaces, and provide a basis for improved design of nanoparticle and extended surface biomaterials.

Graphical abstract: Interactions and visualization of bio-mimetic membrane detachment at smooth and nano-rough gold electrode surfaces

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Publication details

The article was received on 26 Sep 2012, accepted on 11 Apr 2013 and first published on 25 Apr 2013


Article type: Paper
DOI: 10.1039/C3SM27217F
Soft Matter, 2013,9, 5231-5238

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    Interactions and visualization of bio-mimetic membrane detachment at smooth and nano-rough gold electrode surfaces

    S. H. Donaldson, M. Valtiner, M. A. Gebbie, J. Harada and J. N. Israelachvili, Soft Matter, 2013, 9, 5231
    DOI: 10.1039/C3SM27217F

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