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Issue 35, 2013
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Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

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Abstract

We investigate the kinetics of supported lipid bilayer formation by the adsorption and rupture of uncharged phosphatidylcholine lipid vesicles on to a solid substrate. We model the adsorption process taking into account the distinct vesicle rupture events and growth processes. This includes (i) the initial adhesion and vesicle rupture that nucleates bilayer islands, (ii) the growth and merger of bilayer islands, (iii) enhanced adhesion of vesicles to the bilayer edge, and (iv) the final desorption of excess vesicles from the substrate. These simulation studies give insight into prior experimental observations of adsorption in which an overloading of lipid on the solid substrate occurs before formation of the final supported lipid bilayer. Our model provides an explanation for the features of the interesting universal master curve that was observed for the surface fluorescence intensity in the experimental investigations of Weirich et al.

Graphical abstract: Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

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Article information


Submitted
12 Feb 2013
Accepted
12 Jun 2013
First published
14 Jun 2013

This article is Open Access

Soft Matter, 2013,9, 8420-8427
Article type
Paper

Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

P. Plunkett, B. A. Camley, K. L. Weirich, J. Israelachvili and P. J. Atzberger, Soft Matter, 2013, 9, 8420
DOI: 10.1039/C3SM50443C

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