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Issue 29, 2013
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Tunable and dynamic soft materials for three-dimensional cell culture

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Abstract

The human body is complex and hierarchically structured, composed of cells residing within the extracellular matrix (ECM) of tissues that are assembled into organs, all working together to complete a given function. One goal of current biomaterials research is to capture some of this complexity outside of the body for understanding the underlying biology of development, repair, and disease and to devise new strategies for regenerative medicine or disease treatment. Polymeric materials have arisen as powerful tools to mimic the native ECM, giving experimenters a way to capture key aspects of the native cellular environment outside of the body. In particular, dynamic materials allow changes in the properties of these ECM mimics during an experiment, affording an additional degree of control for the experimenter. In this tutorial review, the basic cellular processes of cell migration, proliferation, and differentiation will be overviewed to motivate design considerations for polymeric ECM mimics, and examples will be given of how classes of dynamic materials are being used to study each cellular process.

Graphical abstract: Tunable and dynamic soft materials for three-dimensional cell culture

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Publication details

The article was received on 21 Jan 2013, accepted on 01 Mar 2013 and first published on 13 Mar 2013


Article type: Tutorial Review
DOI: 10.1039/C3SM50217A
Soft Matter, 2013,9, 6737-6746
  • Open access: Creative Commons BY license
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    Tunable and dynamic soft materials for three-dimensional cell culture

    M. S. Rehmann and A. M. Kloxin, Soft Matter, 2013, 9, 6737
    DOI: 10.1039/C3SM50217A

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