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Issue 15, 2013
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Tuning the amino acid sequence of minimalist peptides to present biological signals via charge neutralised self assembly

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Abstract

Nanofibrous materials yielded by the self-assembly of peptides are rich in potential; particularly for the formation of scaffolds that mimic the landscape of the host environment of the cell. Here, we report a novel methodology to direct the formation of supramolecular structures presenting desirable amino acid sequences by the self-assembly of minimalist peptides which cannot otherwise yield the desired scaffold structures under biologically relevant conditions. Through the rational modification of the pKa, we were able to optimise ordered charge neutralised assembly towards in vivo conditions.

Graphical abstract: Tuning the amino acid sequence of minimalist peptides to present biological signals via charge neutralised self assembly

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Supplementary files

Article information


Submitted
30 Nov 2012
Accepted
26 Feb 2013
First published
11 Mar 2013

Soft Matter, 2013,9, 3915-3919
Article type
Communication

Tuning the amino acid sequence of minimalist peptides to present biological signals via charge neutralised self assembly

A. L. Rodriguez, C. L. Parish, D. R. Nisbet and R. J. Williams, Soft Matter, 2013, 9, 3915
DOI: 10.1039/C3SM27758E

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