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Issue 4, 2013
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Interfacing biodegradable molecular hydrogels with liquid crystals

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A self-assembled Fmoc-peptide hydrogel has been interfaced with a liquid crystal (LC) display to give an optical sensor for enzyme activity. An Fmoc-TL-OMe hydrogel was selected as it can be formed in situ by enzyme-mediated assembly with thermolysin, and undergoes enzyme-mediated diassembly upon subtilisin addition. This enzyme-responsive hydrogel provides a semi-rigid, highly hydrated and biocompatible environment that also holds the LC display in place. A dual layer design was developed, where a phospholipid-loaded upper gel layer was separated from the LC display by a phospholipid free lower layer. Subtilisin (0.15 μM) digested both layers to give a gel-to-sol transition after several hours that liberated the phospholipid and produced a light-to-dark optical change in the LC display. The optical response was dependent upon the gel-to-sol transition; elastase or common components of serum did not disassemble the Fmoc-TL-OMe hydrogel and did not give an optical response.

Graphical abstract: Interfacing biodegradable molecular hydrogels with liquid crystals

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Supplementary files

Article information

19 Sep 2012
12 Nov 2012
First published
26 Nov 2012

Soft Matter, 2013,9, 1188-1193
Article type

Interfacing biodegradable molecular hydrogels with liquid crystals

I. Lin, L. S. Birchall, N. Hodson, R. V. Ulijn and S. J. Webb, Soft Matter, 2013, 9, 1188
DOI: 10.1039/C2SM27160E

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