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Issue 4, 2013
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Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(l-lysine) double hydrophilic block copolymers in aqueous solution

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Abstract

The synthesis and the aggregation behavior of novel well-defined poly(N,N-diethylacrylamide)-b-poly(L-lysine) (PDEAm-b-PLL) double hydrophilic block copolymers are reported. PDEAm-b-PLL was prepared using an original strategy which consisted of the ring opening polymerization (ROP) of Nε-trifluoroacetyl-L-lysine N-carboxyanhydride using terminated-thiol PDEAm as a macroinitiator. After deprotection of the amine group of the L-lysine, pH- and thermo-sensitive poly(N,N-diethylacrylamide)-b-poly(L-lysine) block copolymers were obtained. The structure of the copolymers was characterized by 1H NMR and FT-IR. Then, pH and temperature sensitivities were measured by 1H NMR and UV/Vis spectroscopy. At different pH values and temperatures, poly(L-lysine) and poly(N,N-diethylacrylamide) showed typical behaviors, which led to different types of aggregation in aqueous solution. The influence of both stimuli was carefully investigated by DLS, TEM, and SANS.

Graphical abstract: Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(l-lysine) double hydrophilic block copolymers in aqueous solution

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Article information


Submitted
04 Sep 2012
Accepted
12 Nov 2012
First published
30 Nov 2012

Soft Matter, 2013,9, 1301-1309
Article type
Paper

Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(L-lysine) double hydrophilic block copolymers in aqueous solution

X. Zhang, S. Monge, M. In, O. Giani and J. Robin, Soft Matter, 2013, 9, 1301
DOI: 10.1039/C2SM27051J

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