Jump to main content
Jump to site search

Issue 4, 2013
Previous Article Next Article

Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(L-lysine) double hydrophilic block copolymers in aqueous solution

Author affiliations

Abstract

The synthesis and the aggregation behavior of novel well-defined poly(N,N-diethylacrylamide)-b-poly(L-lysine) (PDEAm-b-PLL) double hydrophilic block copolymers are reported. PDEAm-b-PLL was prepared using an original strategy which consisted of the ring opening polymerization (ROP) of Nε-trifluoroacetyl-L-lysine N-carboxyanhydride using terminated-thiol PDEAm as a macroinitiator. After deprotection of the amine group of the L-lysine, pH- and thermo-sensitive poly(N,N-diethylacrylamide)-b-poly(L-lysine) block copolymers were obtained. The structure of the copolymers was characterized by 1H NMR and FT-IR. Then, pH and temperature sensitivities were measured by 1H NMR and UV/Vis spectroscopy. At different pH values and temperatures, poly(L-lysine) and poly(N,N-diethylacrylamide) showed typical behaviors, which led to different types of aggregation in aqueous solution. The influence of both stimuli was carefully investigated by DLS, TEM, and SANS.

Graphical abstract: Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(l-lysine) double hydrophilic block copolymers in aqueous solution

Back to tab navigation

Publication details

The article was received on 04 Sep 2012, accepted on 12 Nov 2012 and first published on 30 Nov 2012


Article type: Paper
DOI: 10.1039/C2SM27051J
Soft Matter, 2013,9, 1301-1309

  •   Request permissions

    Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(L-lysine) double hydrophilic block copolymers in aqueous solution

    X. Zhang, S. Monge, M. In, O. Giani and J. Robin, Soft Matter, 2013, 9, 1301
    DOI: 10.1039/C2SM27051J

Search articles by author

Spotlight

Advertisements