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Issue 9, 2013
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Templation-induced re-equilibration in polymer-scaffolded dynamic combinatorial libraries leads to enhancements in binding affinities

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Abstract

Addition of macromolecular templates to Polymer-Scaffolded Dynamic Combinatorial Libraries (PS-DCLs) constructed by the reversible conjugation of acylhydrazides onto aldehyde-functionalised polymer scaffolds has been shown to generate a population of polymers with enhanced binding affinities towards templates, as determined by a fluorescence-based method. The templating process, which harnesses electrostatic interactions between library members and templates, has been shown to be reversible, with PS-DCLs returning to their initial composition upon removal of the template. Solid-supported templates have been employed for the convenient isolation of the best-binding fraction of the library.

Graphical abstract: Templation-induced re-equilibration in polymer-scaffolded dynamic combinatorial libraries leads to enhancements in binding affinities

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Supplementary files

Article information


Submitted
21 May 2013
Accepted
03 Jul 2013
First published
03 Jul 2013

Chem. Sci., 2013,4, 3661-3666
Article type
Edge Article

Templation-induced re-equilibration in polymer-scaffolded dynamic combinatorial libraries leads to enhancements in binding affinities

C. S. Mahon and D. A. Fulton, Chem. Sci., 2013, 4, 3661
DOI: 10.1039/C3SC51413G

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