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Issue 9, 2013
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Discovery of energy transfer nanostructures using gelation-driven dynamic combinatorial libraries

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Abstract

Peptide self-assembly provides a useful approach to control the organization of functional molecular components, as relevant to future opto-electronic or photonic nanostructures. In this article, we report on the discovery of efficient energy transfer nanostructures using a dynamic combinatorial library (DCL) approach driven by molecular self-assembly, demonstrating an enhanced self-selection and amplification of effective energy transfer nanostructures from complex mixtures of dipeptide derivatives. By taking advantage of an enzyme-catalysed fully reversible amide formation reaction, we show how gelation shifts the equilibrium in favour of the formation of short aromatic dipeptide derivatives in the DCL system, as confirmed by reversed-phase high pressure liquid chromatography (HPLC), fluorescence emission spectroscopy, atomic force microscopy (AFM), transmission force microscopy (TEM) and circular dichroism (CD) spectroscopy. This approach enabled us to identify a two-component donor–acceptor hydrogel, which forms within minutes and exhibits efficient energy transfer.

Graphical abstract: Discovery of energy transfer nanostructures using gelation-driven dynamic combinatorial libraries

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Supplementary files

Article information


Submitted
18 Apr 2013
Accepted
01 Jul 2013
First published
02 Jul 2013

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2013,4, 3699-3705
Article type
Edge Article

Discovery of energy transfer nanostructures using gelation-driven dynamic combinatorial libraries

S. K. M. Nalluri and R. V. Ulijn, Chem. Sci., 2013, 4, 3699
DOI: 10.1039/C3SC51036K

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