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Issue 5, 2013
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Efficient approach for the design of effective chiral quaternary phosphonium salts in asymmetric conjugate additions

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Abstract

An efficient approach for the design of chiral quaternary phosphonium bromides as chiral phase-transfer catalysts was demonstrated. A catalyst library of phosphonium salts with various structures was readily constructed using commercially available chiral phosphines as catalyst precursors, and an optimized catalyst was successfully applied to highly enantioselective conjugate additions under base-free phase-transfer conditions with low catalyst loading.

Graphical abstract: Efficient approach for the design of effective chiral quaternary phosphonium salts in asymmetric conjugate additions

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Publication details

The article was received on 03 Dec 2012, accepted on 26 Feb 2013 and first published on 26 Feb 2013


Article type: Edge Article
DOI: 10.1039/C3SC22130J
Chem. Sci., 2013,4, 2248-2252

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    Efficient approach for the design of effective chiral quaternary phosphonium salts in asymmetric conjugate additions

    S. Shirakawa, A. Kasai, T. Tokuda and K. Maruoka, Chem. Sci., 2013, 4, 2248
    DOI: 10.1039/C3SC22130J

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