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Issue 10, 2013
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Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids

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Abstract

A palladium-catalyzed alkylation of primary and secondary C(sp3)–H bonds with alkyl iodides and/or bromides for the synthesis of optically active unnatural α-amino acids (α-AAs) is described. This process is scalable and tolerates a variety of functional groups with complete retention of chirality, providing an efficient new strategy for the synthesis of various unnatural α-amino acid derivatives.

Graphical abstract: Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids

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Supplementary files

Article information


Submitted
22 Jun 2013
Accepted
23 Jul 2013
First published
24 Jul 2013

Chem. Sci., 2013,4, 3906-3911
Article type
Edge Article

Pd(II)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids

K. Chen, F. Hu, S. Zhang and B. Shi, Chem. Sci., 2013, 4, 3906
DOI: 10.1039/C3SC51747K

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