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Issue 10, 2013
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Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

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Abstract

An anti-candidiasis glycoconjugate vaccine was prepared via a tyrosine-selective alkynylation and a click chemistry mediated glycoconjugation sequence. It features a well-defined glycan, protein carrier, and connectivity. The construct, although with significantly lower carbohydrate loading and a shorter β-(1,3) glucan chain than the well-established anti-candidiasis vaccine derived from the random conjugation of laminarin at lysines, elicited a comparable level of specific IgG antibodies.

Graphical abstract: Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

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Article information


Submitted
18 Jun 2013
Accepted
28 Jun 2013
First published
01 Jul 2013

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2013,4, 3827-3832
Article type
Edge Article

Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy

Q. Hu, M. Allan, R. Adamo, D. Quinn, H. Zhai, G. Wu, K. Clark, J. Zhou, S. Ortiz, B. Wang, E. Danieli, S. Crotti, M. Tontini, G. Brogioni and F. Berti, Chem. Sci., 2013, 4, 3827
DOI: 10.1039/C3SC51694F

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