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Issue 2, 2013
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Proof of principle for a molecular 1 : 2 demultiplexer to function as an autonomously switching theranostic device

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Abstract

Guided by the digital design concepts, we synthesized a two-module molecular demultiplexer (DEMUX) where the output is switched between emission at near IR, and cytotoxic singlet oxygen, with light at 625 nm as the input (I), and acid as the control (c). In the neutral form, the compound fluoresces brightly under excitation at 625 nm, however, acid addition moves the absorption bands of the two modules in opposite directions, resulting in an effective reversal of excitation energy transfer direction, with a concomitant upsurge of singlet oxygen generation and decrease in emission intensity.

Graphical abstract: Proof of principle for a molecular 1 : 2 demultiplexer to function as an autonomously switching theranostic device

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Supplementary files

Article information


Submitted
11 Sep 2012
Accepted
16 Oct 2012
First published
16 Oct 2012

Chem. Sci., 2013,4, 858-862
Article type
Edge Article

Proof of principle for a molecular 1 : 2 demultiplexer to function as an autonomously switching theranostic device

S. Erbas-Cakmak, O. A. Bozdemir, Y. Cakmak and E. U. Akkaya, Chem. Sci., 2013, 4, 858
DOI: 10.1039/C2SC21499G

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