Jump to main content
Jump to site search

Issue 35, 2013
Previous Article Next Article

An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

Author affiliations

Abstract

We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA > glutamate > kainate > DNQX, which explains published experimental data on GluR2 activation and antagonism strength.

Graphical abstract: An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

Back to tab navigation

Article information


Submitted
01 May 2013
Accepted
20 Jul 2013
First published
22 Jul 2013

RSC Adv., 2013,3, 14988-14992
Article type
Communication

An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor

A. C. V. Martins, P. de Lima-Neto, I. L. Barroso-Neto, B. S. Cavada, V. N. Freire and E. W. S. Caetano, RSC Adv., 2013, 3, 14988
DOI: 10.1039/C3RA42149J

Social activity

Search articles by author

Spotlight

Advertisements