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Issue 18, 2013
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Facile and efficient N-arylation of amino acid esters with (−)-methyl-3-dehydroshikimiate(3-MDHS): a bio-based and metal-free strategy leading to N-aryl amino acid derivatives

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Abstract

A novel and convenient bio-based protocol for the preparation of N-aryl amino acid derivatives from (−)-methyl-3-dehydroshikimate and amino acid esters via tandem cross-coupling and aromatization reactions has been developed. Various N-aryl amino acid esters were synthesized in moderate to high yields under mild and metal-free conditions without using aryl halides.

Graphical abstract: Facile and efficient N-arylation of amino acid esters with (−)-methyl-3-dehydroshikimiate(3-MDHS): a bio-based and metal-free strategy leading to N-aryl amino acid derivatives

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Article information


Submitted
15 Dec 2012
Accepted
19 Feb 2013
First published
20 Feb 2013

RSC Adv., 2013,3, 6545-6552
Article type
Paper

Facile and efficient N-arylation of amino acid esters with (−)-methyl-3-dehydroshikimiate(3-MDHS): a bio-based and metal-free strategy leading to N-aryl amino acid derivatives

Y. Zou, E. Zhang, T. Xu, W. Wu, Y. Chen, M. Yuan, W. Wei and X. Zhang, RSC Adv., 2013, 3, 6545
DOI: 10.1039/C3RA40650D

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