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Issue 47, 2013
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Multifunctional graphene quantum dots-conjugated titanate nanoflowers for fluorescence-trackable targeted drug delivery

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Abstract

Multifunctional graphene quantum dots (GQDs) conjugated layered protonated titanate (LPT) nanoflowers have been developed as a promising system for fluorescence imaging and targeted drug delivery. The layered structure of the titanate nanoflowers provides a high specific area for loading drugs. The negatively charged nanocarrier shows a high loading capacity for doxorubicin (DOX). The fluorescence of GQDs reveals the intracellular localization of nanocarriers, suggesting that the uptake is via active endocytosis. Anti-HER2 labelling not only enables rapid uptake into HER2-overexpressing cancer cells, but also improves the nuclear accumulation of DOX. While the drug-free nanocarriers are highly biocompatible for up to 200 μg mL−1, the DOX loaded nanocarriers are more potent than free DOX in anticancer therapy. It is demonstrated that the anti-HER2–GQD–LPT system is a promising platform for simultaneous cancer imaging and anticancer therapeutics.

Graphical abstract: Multifunctional graphene quantum dots-conjugated titanate nanoflowers for fluorescence-trackable targeted drug delivery

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Supplementary files

Article information


Submitted
03 Aug 2013
Accepted
14 Oct 2013
First published
16 Oct 2013

RSC Adv., 2013,3, 24853-24857
Article type
Communication

Multifunctional graphene quantum dots-conjugated titanate nanoflowers for fluorescence-trackable targeted drug delivery

X. T. Zheng, H. L. He and C. M. Li, RSC Adv., 2013, 3, 24853
DOI: 10.1039/C3RA44125C

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