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Issue 43, 2013
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Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] in t-BuOH–H2O using tris(2-morpholinophenyl)phosphine as a ligand

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Abstract

A practical method for the synthesis of various aryl/heteroaryl nitriles using non-toxic K4[Fe(CN)6] as the cyanide source is described. The cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] proceeded smoothly in the presence of a Pd/tris(2-morpholinophenyl)phosphine (L5) catalyst under mild conditions. The corresponding aryl/heteroaryl nitriles were produced in good to excellent yields.

Graphical abstract: Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] in t-BuOH–H2O using tris(2-morpholinophenyl)phosphine as a ligand

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Supplementary files

Article information


Submitted
28 Jun 2013
Accepted
16 Aug 2013
First published
19 Aug 2013

RSC Adv., 2013,3, 20379-20384
Article type
Paper

Efficient palladium-catalyzed cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6] in t-BuOH–H2O using tris(2-morpholinophenyl)phosphine as a ligand

T. Zou, X. Feng, H. Liu, X. Yu, Y. Yamamoto and M. Bao, RSC Adv., 2013, 3, 20379 DOI: 10.1039/C3RA43279C

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