Issue 16, 2013

Microstructure analysis of biocompatible phosphoester copolymers


Copolymers with varying compositions of 2-ethoxy-2-oxo-1,3,2-dioxaphospholane (EEP) and 2-ethoxy-4-methyl-2-oxo-1,3,2-dioxaphospholane (EMEP) have been synthesized via 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed anionic ring-opening polymerization. The molecular weights and comonomer ratios were well controlled and polymers with reasonable molecular weight distributions (<1.5) were obtained in all cases. The copolymers were investigated by 1H and 31P NMR spectroscopies to determine the underlying microstructure via detailed dyad analysis. The copolymers were found to be nontoxic to HeLa cells. Furthermore, the obtained copolymers of EEP and EMEP show thermoresponsive properties, i.e., exhibit a lower critical solution temperature (LCST).

Graphical abstract: Microstructure analysis of biocompatible phosphoester copolymers

Supplementary files

Article information

Article type
02 May 2013
05 Jun 2013
First published
06 Jun 2013
This article is Open Access
Creative Commons BY license

Polym. Chem., 2013,4, 4469-4479

Microstructure analysis of biocompatible phosphoester copolymers

T. Steinbach, R. Schröder, S. Ritz and F. R. Wurm, Polym. Chem., 2013, 4, 4469 DOI: 10.1039/C3PY00563A

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