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Issue 38, 2013
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Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

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Abstract

This review provides a literature overview of bioorthogonal ligation methods for protein modification, which have largely evolved over the last 15 years. Since 1990, various new reactions have been developed that do not involve naturally occurring functional handles. Especially the development of such so-called bioorthogonal ligations has significantly contributed to our ability to selectively modify biomolecules not only in the test tube, but also in living systems.

Graphical abstract: Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

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Publication details

The article was received on 27 Jun 2013, accepted on 06 Aug 2013 and first published on 08 Aug 2013


Article type: Perspective
DOI: 10.1039/C3OB41329B
Org. Biomol. Chem., 2013,11, 6439-6455

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    Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

    M. F. Debets, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2013, 11, 6439
    DOI: 10.1039/C3OB41329B

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