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Issue 38, 2013
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Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

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Abstract

This review provides a literature overview of bioorthogonal ligation methods for protein modification, which have largely evolved over the last 15 years. Since 1990, various new reactions have been developed that do not involve naturally occurring functional handles. Especially the development of such so-called bioorthogonal ligations has significantly contributed to our ability to selectively modify biomolecules not only in the test tube, but also in living systems.

Graphical abstract: Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

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Article information


Submitted
27 Jun 2013
Accepted
06 Aug 2013
First published
08 Aug 2013

Org. Biomol. Chem., 2013,11, 6439-6455
Article type
Perspective

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

M. F. Debets, J. C. M. van Hest and F. P. J. T. Rutjes, Org. Biomol. Chem., 2013, 11, 6439
DOI: 10.1039/C3OB41329B

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