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Issue 34, 2013
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Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

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Abstract

A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a chemiluminescent enzyme-linked immunosorbent assay with sera from patients with chronic Chagas disease. Our data revealed the disaccharide Galα(1,3)Galβ as the immunodominant glycotope, which may eventually be employed as a diagnostic antigen for Chagas disease.

Graphical abstract: Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

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Article information


Submitted
30 Apr 2013
Accepted
02 Jul 2013
First published
02 Jul 2013

Org. Biomol. Chem., 2013,11, 5579-5583
Article type
Communication

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

R. A. Ashmus, N. S. Schocker, Y. Cordero-Mendoza, A. F. Marques, E. Y. Monroy, A. Pardo, L. Izquierdo, M. Gállego, J. Gascon, I. C. Almeida and K. Michael, Org. Biomol. Chem., 2013, 11, 5579
DOI: 10.1039/C3OB40887F

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