Jump to main content
Jump to site search

Issue 31, 2013
Previous Article Next Article

Direct C–H sulfenylation of purines and deazapurines

Author affiliations

Abstract

A general method for Cu-catalyzed C–H sulfenylation of purines, 7-deaza- and 9-deazapurines with aryl- or alkyldisulfides has been developed. In purines, the reaction occurs at position 8, in 7-deazapurines at position 7 and in 9-deazapurines at position 9, leading to new interesting arylsulfanyl derivatives of purine or deazapurine bases. The resulting 8-arylsulfanylpurines undergo Liebesking–Srogl coupling with arylstannanes or boronic acids, whereas the (arylsulfanyl)deazapurines are not reactive under these conditions.

Graphical abstract: Direct C–H sulfenylation of purines and deazapurines

Back to tab navigation

Supplementary files

Article information


Submitted
29 Apr 2013
Accepted
11 Jun 2013
First published
12 Jun 2013

This article is Open Access

Org. Biomol. Chem., 2013,11, 5189-5193
Article type
Paper

Direct C–H sulfenylation of purines and deazapurines

M. Klečka, R. Pohl, J. Čejka and M. Hocek, Org. Biomol. Chem., 2013, 11, 5189
DOI: 10.1039/C3OB40881G

Social activity

Search articles by author

Spotlight

Advertisements