Issue 37, 2013

Pd(0)-catalyzed benzylic arylation–oxidation of 4-methylquinazolines via sp3 C–H activation under air conditions

Abstract

An efficient and selective Pd(0)-catalyzed sp3 C–H bond arylation–oxidation of 4-methylquinazolines is reported. The method enables the introduction of arylketone at the benzylic position of 4-methylquinazolines without the use of an additional directing group, and atmospheric oxygen is used as the sole oxidant.

Graphical abstract: Pd(0)-catalyzed benzylic arylation–oxidation of 4-methylquinazolines via sp3 C–H activation under air conditions

Supplementary files

Article information

Article type
Communication
Submitted
19 Jul 2013
Accepted
01 Aug 2013
First published
02 Aug 2013

Org. Biomol. Chem., 2013,11, 6246-6249

Pd(0)-catalyzed benzylic arylation–oxidation of 4-methylquinazolines via sp3 C–H activation under air conditions

D. Zhao, M. Zhu, Y. Wang, Q. Shen and J. Li, Org. Biomol. Chem., 2013, 11, 6246 DOI: 10.1039/C3OB41488D

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