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Issue 36, 2013
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Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes

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Abstract

We report the synthesis and assembly of umbrella-rotaxanes with transmembrane transport properties. We describe their amphomorphism and validate their ability to penetrate and cross phospholipid bilayers. Furthermore we present the strategy to release the macrocyclic compound by enzymatic cleavage inside egg yolk phosphatidylcholine (EYPC) liposomes.

Graphical abstract: Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes

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Publication details

The article was received on 11 Jun 2013, accepted on 24 Jul 2013 and first published on 25 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB41209A
Org. Biomol. Chem., 2013,11, 6023-6028

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    Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes

    C. Chhun, J. Richard-Daniel, J. Kempf and A. R. Schmitzer, Org. Biomol. Chem., 2013, 11, 6023
    DOI: 10.1039/C3OB41209A

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