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Issue 36, 2013
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Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes

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Abstract

We report the synthesis and assembly of umbrella-rotaxanes with transmembrane transport properties. We describe their amphomorphism and validate their ability to penetrate and cross phospholipid bilayers. Furthermore we present the strategy to release the macrocyclic compound by enzymatic cleavage inside egg yolk phosphatidylcholine (EYPC) liposomes.

Graphical abstract: Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes

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Article information


Submitted
11 Jun 2013
Accepted
24 Jul 2013
First published
25 Jul 2013

Org. Biomol. Chem., 2013,11, 6023-6028
Article type
Paper

Transport of macrocyclic compounds across phospholipid bilayers by umbrella-rotaxanes

C. Chhun, J. Richard-Daniel, J. Kempf and A. R. Schmitzer, Org. Biomol. Chem., 2013, 11, 6023
DOI: 10.1039/C3OB41209A

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