Issue 22, 2013

Transition metal-catalyzed functionalization of pyrazines


Transition metal-catalyzed reactions are generally used for carbon–carbon bond formation on pyrazines and include, but are not limited to, classical palladium-catalyzed reactions like Sonogashira, Heck, Suzuki, and Stille reactions. Also a few examples of carbon–heteroatom bond formation in pyrazines are known. This perspective reviews recent progress in the field of transition metal-catalyzed cross-coupling reactions on pyrazine systems. It deals with the most important C–C- and C–X-bond formation methodologies.

Graphical abstract: Transition metal-catalyzed functionalization of pyrazines

Article information

Article type
06 Mar 2013
08 Apr 2013
First published
09 Apr 2013
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2013,11, 3583-3602

Transition metal-catalyzed functionalization of pyrazines

N. I. Nikishkin, J. Huskens and W. Verboom, Org. Biomol. Chem., 2013, 11, 3583 DOI: 10.1039/C3OB40460A

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