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Issue 14, 2013
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N-Heterocyclic carbene–palladium(ii)–1-methylimidazole complex catalyzed Suzuki–Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water

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Abstract

An easily available N-heterocyclic carbene–palladium(II)–1-methylimidazole complex 1 showed efficient catalytic activity in the Suzuki–Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water under mild conditions, providing an alternative method for the synthesis of diarylmethane derivatives, which widely exist in molecules with pharmaceutical activities and are also frequently found as subunits in supramolecules. Under the optimal conditions, all reactions performed well to give the desired products in moderate to almost quantitative yields in an environmentally benign medium within 12 h, extending their applications toward potentially industrial processes.

Graphical abstract: N-Heterocyclic carbene–palladium(ii)–1-methylimidazole complex catalyzed Suzuki–Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water

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Publication details

The article was received on 04 Dec 2012, accepted on 18 Jan 2013 and first published on 04 Feb 2013


Article type: Paper
DOI: 10.1039/C3OB27353A
Org. Biomol. Chem., 2013,11, 2266-2272

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    N-Heterocyclic carbene–palladium(II)–1-methylimidazole complex catalyzed Suzuki–Miyaura coupling of benzylic chlorides with arylboronic acids or potassium phenyltrifluoroborate in neat water

    Y. Zhang, M. Feng and J. Lu, Org. Biomol. Chem., 2013, 11, 2266
    DOI: 10.1039/C3OB27353A

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