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Issue 16, 2013
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Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation

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Abstract

The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene–sugar, ferrocenecyclodextrin, ferrocenepeptide and ferroceneprotein conjugates).

Graphical abstract: Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation

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Publication details

The article was received on 13 Nov 2012, accepted on 29 Jan 2013 and first published on 30 Jan 2013


Article type: Paper
DOI: 10.1039/C3OB27209E
Org. Biomol. Chem., 2013,11, 2586-2596
  • Open access: Creative Commons BY-NC license
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    Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation

    A. Megia-Fernandez, F. Hernandez-Mateo and F. Santoyo-Gonzalez, Org. Biomol. Chem., 2013, 11, 2586
    DOI: 10.1039/C3OB27209E

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