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Issue 16, 2013
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Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation

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Abstract

The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene–sugar, ferrocenecyclodextrin, ferrocenepeptide and ferroceneprotein conjugates).

Graphical abstract: Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation

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Supplementary files

Article information


Submitted
13 Nov 2012
Accepted
29 Jan 2013
First published
30 Jan 2013

This article is Open Access

Org. Biomol. Chem., 2013,11, 2586-2596
Article type
Paper

Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation

A. Megia-Fernandez, F. Hernandez-Mateo and F. Santoyo-Gonzalez, Org. Biomol. Chem., 2013, 11, 2586
DOI: 10.1039/C3OB27209E

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