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Issue 16, 2013
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A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

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Abstract

To circumvent the limitations of polyethylene glycol (PEG) modified carriers, a photo-triggerable liposome was prepared which was modified by cholesterol derivatives via a cleavable vinyl ether linkage so that the PEGylated coating can be efficiently removed by a photoactivated fullerene. After the photocleavage of the PEG moiety, the intracellular uptake of the photo-triggerable liposome improved.

Graphical abstract: A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

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Publication details

The article was received on 12 Nov 2012, accepted on 19 Dec 2012 and first published on 20 Dec 2012


Article type: Communication
DOI: 10.1039/C2OB27199K
Org. Biomol. Chem., 2013,11, 2567-2570

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    A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

    C. Komeda, A. Ikeda, J. Kikuchi, N. Ishida-Kitagawa, H. Tatebe, K. Shiozaki and M. Akiyama, Org. Biomol. Chem., 2013, 11, 2567
    DOI: 10.1039/C2OB27199K

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