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Issue 2, 2013
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Use of benzynes for the synthesis of heterocycles

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Abstract

About two decades after Kobayashi's discovery in 1983 of a very mild way of generating highly reactive aryne intermediates, the synthetic community embraced o-(trimethylsilyl)aryl triflates as convenient and versatile aryne precursors for the synthesis of carbocycles and heterocycles, as well as natural products and pharmaceutically promising drug candidates. This review provides a comprehensive overview of the construction of heterocycles using Kobayashi's silylaryl triflate aryne precursors. It is organized according to the type of heterocycle generated.

Graphical abstract: Use of benzynes for the synthesis of heterocycles

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Article information


Submitted
24 Aug 2012
Accepted
22 Oct 2012
First published
06 Nov 2012

Org. Biomol. Chem., 2013,11, 191-218
Article type
Perspective

Use of benzynes for the synthesis of heterocycles

A. V. Dubrovskiy, N. A. Markina and R. C. Larock, Org. Biomol. Chem., 2013, 11, 191
DOI: 10.1039/C2OB26673C

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