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Issue 15, 2013
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VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle

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Abstract

Herein we report the design and synthesis of multifunctional VEGF-loaded IR800-conjugated graphene oxide (GO-IR800-VEGF) for multi-modality imaging-monitored therapeutic angiogenesis of ischemic muscle. The as-prepared GO-IR800-VEGF positively targets VEGF receptors, maintains an elevated level of VEGF in ischemic tissues for a prolonged time, and finally leads to remarkable therapeutic angiogenesis of ischemic muscle. Although more efforts are required to further understand the in vivo behaviors and the long-term toxicology of GO, our work demonstrates the success of using GO for efficient VEGF delivery in vivo by intravenous administration and suggests the great promise of using graphene oxide in theranostic applications for treating ischemic disease.

Graphical abstract: VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle

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Article information


Submitted
30 Mar 2013
Accepted
15 May 2013
First published
20 May 2013

Nanoscale, 2013,5, 6857-6866
Article type
Paper

VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle

Z. Sun, P. Huang, G. Tong, J. Lin, A. Jin, P. Rong, L. Zhu, L. Nie, G. Niu, F. Cao and X. Chen, Nanoscale, 2013, 5, 6857
DOI: 10.1039/C3NR01573D

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