Issue 9, 2013

Surface-modified multifunctional MIP nanoparticles


The synthesis of core–shell molecularly imprinted polymer nanoparticles (MIP NPs) has been performed using a novel solid-phase approach on immobilised templates. The same solid phase also acts as a protective functionality for high affinity binding sites during subsequent derivatisation/shell formation. This procedure allows for the rapid synthesis, controlled separation and purification of high-affinity materials, with each production cycle taking just 2 hours. The aim of this approach is to synthesise uniformly sized imprinted materials at the nanoscale which can be readily grafted with various polymers without affecting their affinity and specificity. For demonstration purposes we grafted anti-melamine MIP NPs with coatings which introduce the following surface characteristics: high polarity (PEG methacrylate); electro-activity (vinylferrocene); fluorescence (eosin acrylate); thiol groups (pentaerythritol tetrakis(3-mercaptopropionate)). The method has broad applicability and can be used to produce multifunctional imprinted nanoparticles with potential for further application in the biosensors, diagnostics and biomedical fields and as an alternative to natural receptors.

Graphical abstract: Surface-modified multifunctional MIP nanoparticles

Supplementary files

Article information

Article type
05 Dec 2012
21 Feb 2013
First published
26 Feb 2013

Nanoscale, 2013,5, 3733-3741

Surface-modified multifunctional MIP nanoparticles

E. Moczko, A. Poma, A. Guerreiro, I. Perez de Vargas Sansalvador, S. Caygill, F. Canfarotta, M. J. Whitcombe and S. Piletsky, Nanoscale, 2013, 5, 3733 DOI: 10.1039/C3NR00354J

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