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Issue 4, 2013
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Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials

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Abstract

To date, graphene oxide (GO), an oxidized version of graphene, has been utilized in many research areas including bioapplications such as drug delivery and bioanalysis. Unlike other spherical or polygonal nanomaterials, GO exhibits a sheet-like structure, which in itself suggests interesting applications based on its shape. Here we show that GO can protect cells from internalization of toxic hydrophobic molecules, nanoparticles, and nucleic acids such as siRNA and plasmid DNA by interacting with cell surface lipid bilayers without noticeably reducing cell viability. Furthermore, the cytoprotective effect of GO against the internalization of extracellular materials enabled spatial control over gene transfection through region-selective gene delivery only into GO-untreated cells, and not into the GO-treated cells.

Graphical abstract: Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials

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Supplementary files

Article information


Submitted
21 Aug 2012
Accepted
14 Dec 2012
First published
18 Dec 2012

Nanoscale, 2013,5, 1669-1677
Article type
Paper

Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials

H. Na, M. Kim, J. Lee, Y. Kim, H. Jang, K. E. Lee, H. Park, W. Do Heo, H. Jeon, I. S. Choi, Y. Lee and D. Min, Nanoscale, 2013, 5, 1669
DOI: 10.1039/C2NR33800A

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