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Issue 12, 2013
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Doped semiconductor nanocrystal based fluorescent cellular imaging probes

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Abstract

Doped semiconductor nanocrystals such as Mn doped ZnS, Mn doped ZnSe and Cu doped InZnS, are considered as new classes of fluorescent biological probes with low toxicity. Although the synthesis in high quality of such nanomaterials is now well established, transforming them into functional fluorescent probes remains a challenge. Here we report a fluorescent cellular imaging probe made of high quality doped semiconductor nanocrystals. We have identified two different coating approaches suitable for transforming the as synthesized hydrophobic doped semiconductor nanocrystals into water-soluble functional nanoparticles. Following these approaches we have synthesized TAT-peptide- and folate-functionalized nanoparticles of 10–80 nm hydrodynamic diameter and used them as a fluorescent cell label. The results shows that doped semiconductor nanocrystals can be an attractive alternative for conventional cadmium based quantum dots with low toxicity.

Graphical abstract: Doped semiconductor nanocrystal based fluorescent cellular imaging probes

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Supplementary files

Article information


Submitted
31 Jan 2013
Accepted
31 Mar 2013
First published
09 Apr 2013

Nanoscale, 2013,5, 5506-5513
Article type
Paper

Doped semiconductor nanocrystal based fluorescent cellular imaging probes

A. R. Maity, S. Palmal, S. Basiruddin, N. S. Karan, S. Sarkar, N. Pradhan and N. R. Jana, Nanoscale, 2013, 5, 5506 DOI: 10.1039/C3NR00549F

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